Knight BioAdvisors

Selected Publications

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Jordan, R.E., Fernandez, J., Brezski, R., Greenplate, A.R., Knight, D.M., Raju, T.S., and Lynch, A.S. A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity. Immunology Letters 172: 29-39 (2016).

Brezski, R.J., Knight, D.M., and Jordan, R.E., The origins, specificity, and potential biological relevance of human anti-IgG hinge antibodies. ScientificWorldJornal, 11:1153-67 (2011)

Shi, L, Wheeler, J., Sweet, R., Lu, J., Luo, J., Tornetta, M., Whitaker, B., Reddy, R., Brittingham, R., Borozdina, L., Chen, Q., Amegadzie, B., Knight, D., Almagro, J., and Tsui, P., De novo selection of high-affinity antibodies from synthetic Fab libraries displayed on phage as pIX fusion proteins. J. Molec. Biol., 397 (2): 385-96 (2010)

Strohl, W., and Knight, D.M., Discovery and development of biopharmaceuticals: current issues. Current Opinion in Biotechnology 20, 1-5 (2009).

Brezski, R., Vafa, O., Petrone, D., Tam, S., Powers, G., Ryan, M., Luongo, J., Oberholtzer, A, Knight, D., and Jordan, R., Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge. Proc. Nat. Acad. Sci. doi/10.1073/pnas.0904174106.

Brezski, R., Luongo, J., Petrone, D., Ryan, M., Zhong, D., Tam, S., Schmidt, A., Kruszynski, M., Whitaker, B., Knight, D., and Jordan, R., Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs. J. Immunology, September 2008, 181: 3183-3192.

Tornetta, M., Fisher, D., O’Neil, K., Geng, D., Schantz, A., Brigham-Burke, M., Lombardo, D., Fink, D., Knight, D.,Sweet, R., and Tsui, P. Isolation of human anti-idiotypic antibodies by phage display for clinical immune response assays. J. Immunol. Methods 328, 34-44 (2007).

Snyder, L., Goletz, T., Gunn, G., Shi, F., Harris, M., Cochlin, K., McCauley, C., McCarthy, S., Branigan, P., and Knight, D.M. A MUC1/IL-18 DNA vaccine induces long-term anti-tumor immunity in MUC1 transgenic mice, Vaccine 24, 3340-3352 (2006)

Knight, D.M.,  Jordan, R., Kruszynski, M., Tam, S., Giles-Komar, J., Treacy, G., and Heavner, G.A. Pharmacodynamic enhancement of the anti-platelet antibody fab abciximab by site-specific pegylation. Platelets 15, 409-418 (2004).

Treacy, G., and Knight, D.M., Monoclonal Antibodies in Encyclopedic Reference of Immunotoxicology. Springer-Verlag, (2003).

Knight, D.M., Wagner, C., Jordan, R., McAleer, M.F., DeRita, R., Fass, D.N., Coller, B.S., Weisman, H.F., and Ghrayeb, J., The Immunogenicity of the 7E3 Murine Monoclonal Fab Antibody Fragment Variable Region is Dramatically Reduced in Humans by Substitution of Human for Murine Constant Regions. Molecular Immunology 32, 1271-1281 (1995).

Taylor, A.H., Heavner, G., Nedelman, M., Sherris, D., Brunt, E., Knight, D.M., and Ghrayeb, J., Lipopolysaccharide (LPS) Neutralizing Peptides Reveal a Lipid A Binding Site of LPS Binding Protein. J. Biol. Chem. 270, 17934-17938 (1995).

Scallon, B.J., Arevalo Moore, M., Trinh, H., Knight, D.M., and Ghrayeb, J., Chimeric Anti-TNF-α Monoclonal Antibody cA2 Binds Recombinant Transmembrane TNF-α and Activates Immune Effector Functions. Cytokine 7, 251-259 (1995).

Knight, D.M., Trinh, H., Le, J., Siegel, S., Shealy, D., McDonough, M., Scallon, B.,
Arevalo Moore, M., Vilcek, J., Daddona, P., and Ghrayeb, J., Construction and Initial Characterization of a Mouse-human Chimeric Anti-TNF Antibody. Molecular Immunology 30, 1443-1452 (1993).

Dalesandro, M.R., Pak, Y-K., Tam, S., Wilson, E., Looney, J., Knight, D.M., Ghrayeb, J., Reiter, C., Rieber, E.P., Riethmuller, G., and Daddona, P., Effects of Isotype and Fc Region on In Vitro Function of a Mouse/Human Chimeric CD4 Antibody. International Immunology 5, 283-291 (1993).

Looney, J., Knight, D.M., Arevalo Moore, M., Trinh, H., Pak, K-Y., Dalesandro, M., Rieber, E.P., Riethmuller, G., Daddona, P., and Ghrayeb, J., High-level Expression and Characterization of a Mouse-Human Chimeric CD4 Antibody with Therapeutic Potential. Human Antibodies and Hybridomas 3, 191-200 (1992).

Knight, D.M., McDonough, M., Moore, M., Abercombie, D., Siegel, R., and Ghrayeb, J., Stable Expression of Cloned Human Antibody Genes in Murine Myeloma Cells. Human Antibodies and Hybridomas 3, 129-136 (1992).

Coller, B., Scudder, L., Beer, J., Gold, H., Folts, J., Cavagnaro, J., Jordan, R., Wagner, C., Iuliucci, J., Knight, D.M., Ghrayeb, J., Smith, C., and Berger, H., Monoclonal Antibodies to Platelet GPIIb/IIIa as Anti-thrombotic Agents. Proc. N.Y. Acad. Sci. 614,
193-213 (1991).

Knight, D.M., Flomerfelt, F., and Ghrayeb, J., Expression of the Art/trs Protein of HIV and Study of its Role in Viral Envelope Synthesis. Science 236, 837-840 (1987).

Ringold, G.M., Chapman, A., Knight, D.M., Navre, M., and Torti, F.M., Hormonal Control of Adipocyte Differentiation and Adipocyte Gene Expression. In Recent Progress in Hormone Research 44, 115-140 (1988)

Knight, D.M., Dieckman, B., and Ringold, G.M., Requirements for Triggering of Adipocyte Differentiation by Glucocordicoids and Indomethacin. Molecular Endocrinology 1, 86-92 (1986).

Ringold, G.M., Chapman, A., Knight, D.M., and Torti, F., Hormonal Control of Adipogenesis.In Annals of the N.Y. Academy of Sciences Symposium 487, 109-119 (1986).

Knight, D.M., Chapman, A., Torti, F., and Ringold, G.M., Hormonal Control of
Developmentally Regulated Adipose Genes. Cellular Endocrinology, G. Serrero, ed., Alan R. Liss, Inc. (1986).

Ringold, G.M., Chapman, A., and Knight, D.M., Glucocorticoid Control of Developmentally Regulated Adipose Genes. J. Steroid Biochemistry, 24, 69-75 (1986).

Ringold, G.M., Chapman, A., Danielsen, M., Klein, E., Knight, D.M., Northrup, J., and Vannice, J.L.,Glucocorticoid Receptors and the Control of Gene Expression. In 3rd Meadowbrook Symposium. (1985).

Chapman, A., Knight, D.M., and Ringold, G.M., Glucocorticoid Regulation of Adipocyte Differentiation: Hormonal Triggering of the Developmental Program and Induction of a Differentiation-dependent Gene. J .Cell Biology 101, 1227-1235 (1985).

Chapman, A., Knight, D.M., Dieckman, B., and Ringold,
G.M., Analysis of Gene Expression During Differentiation of Adipogenic
Cells in Culture and Hormonal Control of the Developmental Program, J. Biol. Chem. 259, 1548-1555 (1984).

Knight, D.M., and Echols, H., The cIII Gene and Protein of Bacteriophage Lambda. J. Molecular Biology 163, 505-510 (1983).

Hoyt, M.A., Knight, D.M., Das, A., Miller, H., and Echols, H., Control of Phage Lambda Development by Stability and Synthesis of cII Protein: Role of Viral cIII and Host hflA, himA and himD Genes. Cell 31, 565-573 (1982).

Knight, D.M., and Jones, E.E., Regulation of Ornithine Transcarbamylase by Orotate, J.Biol. Chem. 252, 5928-5930 (1977).